Phenotypic Analysis of Genetically Altered Mice

• Evaluate genetic alteration and recommend optimized approach based on anticipated tissue/organ effects
• Design protocols for methods required (histology, immunohistochemistry, clinical chemistry, hematology, etc.)
• Review, correlate, and interpret findings
• Prepare summary report with recommendations for path forward

Benefit: A complete understanding of how the genetic alteration impacts organs increases the predictive value regarding therapeutic potential as well as potential toxicities

• Evaluate animal models for diseases such as osteoarthritis, asthma, and cancer and recommend optimized approach to assessment
• Review methods of model generation to anticipate inherent complications to interpretation
• Design protocols for methods required (histology, histochemical stains, clinical chemistry, hematology, etc.)
• Review, correlate and interpret findings
• Collaborate with investigators to integrate features of the model with pharmacologic and/or behavioral endpoints
• Prepare summary report with recommendations for path forward

Benefit: A complete understanding of the model relative to the actual human disease enhances decision making related to interpreting efficacy study findings

• Develop with investigators a hypothesis-based study design using in vivo models
• Design protocols for required methods (histology, histochemical stains, clinical chemistry, hematology, etc).
• Review methods of model generation to anticipate inherent complications to interpretation
• Review, correlate, and interpret findings
• Prepare summary report with recommendations for path forward

Benefit: The accurate interpretation of well-developed POP studies empowers the decision making process for recommending a path forward into development

• Review target/receptor data and recommend optimized approach to assessment in human and/or animal organs based on anticipated expression patterns
• Evaluate expression patterns in slides and/or review reports using immunohistochemistry or in situ hybridization detection methods
• Review and interpret findings (versus artifacts or nonspecific tissue reactions) in relationship to pharmacology and/or toxicity
• Prepare summary report with recommendations for path forward

Benefit: A clear understanding of RNA/protein tissue expression patterns related to therapeutic targets increases the predictive value regarding therapeutic potential as well as potential toxicities

• Discuss with investigators the objective of the study
• Critically review histology slides, micrographs, and/or reports using these methods
• Evaluate relevance of findings (versus artifacts or nonspecific tissue reactions) in relationship to pharmacology and/or toxicity
• Prepare summary report with recommendations for path forward

	Benefit: The accurate interpretation of special techniques data clarifies the mechanism of organ toxicity in relationship to pharmacology and/or toxicology, and possible human relevance